SCHEMBL8458703

SCHEMBL8458703

COc1ccc(-c2cc(OC)ccc2C(=O)c2ccc(O)cc2)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.59
ALDH1A1 P00352 5/20 0.56
LMNA P02545 3/20 0.56
CYP1A2 P05177 3/20 0.56
CYP2C19 P33261 3/20 0.56
HPGD P15428 3/20 0.56
MAPK1 P28482 3/20 0.56
HTT P42858 2/20 0.56
CYP2D6 P10635 2/20 0.56
PGR P06401 1/20 0.56
SLC6A2 P23975 1/20 0.56
PDE4A P27815 1/20 0.56
HRH1 P35367 1/20 0.56
SLC6A3 Q01959 1/20 0.56
PDE4D Q08499 1/20 0.56
CYP2C8 P10632 1/20 0.54
RAB9A P51151 2/20 0.53
MAPT P10636 5/20 0.53
NPSR1 Q6W5P4 1/20 0.53
ESR2 Q92731 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8458977 1.00 NPC1 (0.59) NPC1ALDH1A1LMNACYP1A2CYP2C19
SCHEMBL8460808 0.98 ALDH1A1 (0.57) NPC1ALDH1A1LMNACYP1A2CYP2C19
SCHEMBL8458979 0.94 NPC1 (0.55) NPC1ALDH1A1LMNACYP1A2CYP2C19
SCHEMBL7495907 0.94 NPC1 (0.55) NPC1ALDH1A1LMNACYP1A2CYP2C19
SCHEMBL7502103 0.94 NPC1 (0.66) NPC1ALDH1A1LMNACYP1A2CYP2C19
SCHEMBL8458268 0.93 NPC1 (0.56) NPC1ALDH1A1LMNACYP1A2CYP2C19
SCHEMBL8460805 0.87 BACE1 (0.57) NPC1ALDH1A1LMNACYP1A2CYP2C19
SCHEMBL7101319 0.87 MAPT (0.64) NPC1ALDH1A1LMNACYP1A2CYP2C19
SCHEMBL7102473 0.87 NPC1 (0.57) NPC1ALDH1A1LMNACYP1A2CYP2C19
SCHEMBL8339910 0.86 NPC1 (0.50) NPC1ALDH1A1LMNACYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999025706-A1 2-ARYL-3-AROYLBENZO[B]THIOPHENES USEFUL FOR THE TREATMENT OF ESTROGEN DEPRIVATION SYNDROME ELI LILLY AND COMPANY (US) 1999-05-27 WO claimed
WO-1999025706-A1 2-ARYL-3-AROYLBENZO[B]THIOPHENES USEFUL FOR THE TREATMENT OF ESTROGEN DEPRIVATION SYNDROME ELI LILLY AND COMPANY (US) 1999-05-27 WO disclosed
WO-1999015521-A1 BENZOTHIOPHENES ELI LILLY AND COMPANY (US) 1999-04-01 WO disclosed