Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | EDNRA | P25101 | 1/20 | 0.51 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.48 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.48 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.48 |
| ▸ | RXRA | P19793 | 2/20 | 0.48 |
| ▸ | RXRB | P28702 | 1/20 | 0.48 |
| ▸ | RXRG | P48443 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | LIPE | Q05469 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8682572 | 0.89 | BRD4 (0.51) | TDP1MAPTL3MBTL1MAPK1PTGER1 | |
| SCHEMBL8323310 | 0.89 | BRD4 (0.51) | TDP1MAPTL3MBTL1MAPK1PTGER1 | |
| SCHEMBL27833448 | 0.80 | BRD4 (0.51) | TDP1MAPTL3MBTL1MAPK1PTGER1 | |
| SCHEMBL28060106 | 0.79 | GLRA1 (0.60) | L3MBTL1LMNAALDH1A1 | |
| SCHEMBL28060114 | 0.79 | GLRA1 (0.60) | L3MBTL1LMNAALDH1A1 | |
| SCHEMBL28060142 | 0.79 | GLRA1 (0.60) | L3MBTL1LMNAALDH1A1 | |
| SCHEMBL19612191 | 0.79 | MAPT (1.00) | TDP1MAPTL3MBTL1MAPK1PTGER1 | |
| SCHEMBL3954798 | 0.78 | PTGS2 (0.55) | MAPTL3MBTL1SMN1; SMN2EDNRAKDM4E | |
| SCHEMBL6618364 | 0.78 | HTR2A (0.53) | TDP1MAPTL3MBTL1MAPK1PTGER1 | |
| SCHEMBL8326325 | 0.78 | RXRA (0.49) | TDP1MAPTL3MBTL1MAPK1PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0503563-B1 | Novel 8-substituted purines as selective adenosine receptor agents | MERRELL PHARMA INC (US) | 2003-09-17 | — | — | EP | disclosed |
| US-5208240-A | Alzeheimer's, cardiovascular, respiratory | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-05-04 | — | — | US | disclosed |
| EP-0503563-A2 | Novel 8-substituted purines as selective adenosine receptor agents | MERRELL PHARMACEUTICALS INC. (US) | 1992-09-16 | — | — | EP | disclosed |