Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 11/20 | 0.49 |
| ▸ | CTSS | P25774 | 9/20 | 0.49 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7203913 | 0.84 | MALT1 (0.59) | CTSKMALT1BCHE | |
| SCHEMBL7103984 | 0.83 | CTSK (0.60) | CTSKCTSSCTSLCTSBAKT1 | |
| SCHEMBL7104136 | 0.81 | CYP2D6 (0.58) | CTSKCTSSCTSLCTSBAKT1 | |
| SCHEMBL7102367 | 0.80 | ATM (0.59) | CTSKCTSSCTSLCTSBAKT1 | |
| SCHEMBL4899444 | 0.77 | MALT1 (0.54) | CTSKCTSSMALT1BCHEHDAC1 | |
| SCHEMBL10126784 | 0.76 | MEN1 (0.53) | MALT1BCHE | |
| SCHEMBL7414006 | 0.76 | BACE1 (0.40) | CTSKCTSSCTSLCTSBATM | |
| SCHEMBL13257888 | 0.75 | ATM (0.50) | CTSKCTSSCTSLCTSBATM | |
| SCHEMBL21224591 | 0.75 | TDP1 (0.58) | MALT1 | |
| SCHEMBL13257955 | 0.75 | ATM (0.50) | CTSKCTSSCTSLCTSBATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140818-B1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | AVENTIS PHARMA INC (US) | 2003-09-10 | — | — | EP | disclosed |
| US-6329550-B1 | FOR THERAPY OF EMPHYSEMA, OSTEOPOROSIS, RHEUMATOID ARTHRITIS AND NEOPLASTIC DISEASES | AVENTIS PHARMACEUTICALS INC. | 2001-12-11 | — | — | US | disclosed |
| EP-1140818-A1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | Aventis Pharmaceuticals Inc. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040552-A1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | AVENTIS PHARMACEUTICALS INC. (US) | 2000-07-13 | — | — | WO | disclosed |