Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | CTSS | P25774 | 4/20 | 0.39 |
| ▸ | CTSK | P43235 | 4/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 3/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7417898 | 0.83 | CTSK (0.47) | BACE1CTSSCTSKATMCTSL | |
| SCHEMBL7102658 | 0.76 | CTSK (0.49) | CTSSCTSKATMCTSLCTSB | |
| SCHEMBL7419681 | 0.74 | PPARG (0.44) | CTSKPPARAALDH1A1PPARG | |
| SCHEMBL7203913 | 0.70 | MALT1 (0.59) | CTSK | |
| SCHEMBL13258281 | 0.70 | ATM (0.50) | CTSSCTSKATMCTSLCTSB | |
| SCHEMBL13257888 | 0.70 | ATM (0.50) | CTSSCTSKATMCTSLCTSB | |
| SCHEMBL13257955 | 0.70 | ATM (0.50) | CTSSCTSKATMCTSLCTSB | |
| SCHEMBL12311224 | 0.70 | GBA1 (0.44) | CTSSCTSLCTSBALDH1A1HDAC1 | |
| SCHEMBL9186325 | 0.69 | CA14 (0.55) | BACE1RENALDH1A1HDAC1 | |
| SCHEMBL10126784 | 0.68 | MEN1 (0.53) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140818-A1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | Aventis Pharmaceuticals Inc. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040552-A1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | AVENTIS PHARMACEUTICALS INC. (US) | 2000-07-13 | — | — | WO | disclosed |