Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.60 |
| ▸ | CTSS | P25774 | 4/20 | 0.58 |
| ▸ | CA2 | P00918 | 4/20 | 0.54 |
| ▸ | CTSL | P07711 | 1/20 | 0.54 |
| ▸ | CTSB | P07858 | 1/20 | 0.54 |
| ▸ | AKT1 | P31749 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7104136 | 0.92 | CYP2D6 (0.58) | CTSKCTSSCTSLCTSBAKT1 | |
| SCHEMBL7102367 | 0.86 | ATM (0.59) | CTSKCTSSCA2CTSLCTSB | |
| SCHEMBL7098744 | 0.86 | SMN1; SMN2 (0.55) | CA2NPC1RAB9A | |
| SCHEMBL8416665 | 0.86 | CA2 (0.72) | CTSKCTSSCA2ATM | |
| SCHEMBL6051637 | 0.86 | CTSS (0.74) | CTSKCTSSCA2CTSLCTSB | |
| SCHEMBL572740 | 0.84 | IDO1 (0.60) | CTSKCTSSCA2CYP3A4NPC1 | |
| SCHEMBL10703886 | 0.84 | CTSK (0.61) | CTSKCTSSCA2CTSLCTSB | |
| SCHEMBL9006092 | 0.83 | CA2 (0.74) | CTSKCTSSCA2CTSLCTSB | |
| SCHEMBL9006099 | 0.83 | CA2 (0.74) | CTSKCTSSCA2CTSLCTSB | |
| SCHEMBL7102658 | 0.83 | CTSK (0.49) | CTSKCTSSCTSLCTSBAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140818-B1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | AVENTIS PHARMA INC (US) | 2003-09-10 | — | — | EP | disclosed |
| US-6329550-B1 | FOR THERAPY OF EMPHYSEMA, OSTEOPOROSIS, RHEUMATOID ARTHRITIS AND NEOPLASTIC DISEASES | AVENTIS PHARMACEUTICALS INC. | 2001-12-11 | — | — | US | disclosed |
| EP-1140818-A1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | Aventis Pharmaceuticals Inc. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040552-A1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | AVENTIS PHARMACEUTICALS INC. (US) | 2000-07-13 | — | — | WO | disclosed |