Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | CCR1 | P32246 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29373118 | 0.78 | ACHE (0.49) | MAPTLMNACYP3A4CYP2D6ALOX15 | |
| SCHEMBL232662 | 0.78 | ACHE (0.49) | MAPTLMNACYP3A4CYP2D6ALOX15 | |
| SCHEMBL7018895 | 0.77 | NPC1 (0.43) | KDM4ESMN1; SMN2CYP3A4CYP2D6CCR1 | |
| SCHEMBL30542089 | 0.76 | ACHE (0.48) | MAPTLMNACYP3A4CYP2D6ALOX15 | |
| SCHEMBL9407051 | 0.76 | PAX8 (0.53) | KDM4EMAPTSMN1; SMN2MMP2TSHR | |
| Bromide SCHEMBL28325156 | 0.76 | ACHE (0.48) | MAPTLMNACYP3A4CYP2D6ALOX15 | |
| Bromide SCHEMBL5146705 | 0.76 | ACHE (0.48) | MAPTLMNACYP3A4CYP2D6ALOX15 | |
| Hydrochloric Acid SCHEMBL7823346 | 0.76 | ACHE (0.48) | KDM4EMAPTSMN1; SMN2LMNACYP3A4 | |
| Quinoline SCHEMBL28087030 | 0.76 | ALDH1A1 (0.52) | CYP3A4CYP2D6PAX8RAB9AALDH1A1 | |
| SCHEMBL19566070 | 0.76 | CCR1 (0.52) | KDM4EMAPTSMN1; SMN2MMP2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934320-B1 | NAPHTHYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2003-04-02 | — | — | EP | disclosed |
| US-6136821-A | ANTIINFLAMMATORY AGENTS, ANTIHISTAMINES AND BRONCHODILATOR AGENTS | NOVARTIS AG (CH) | 2000-10-24 | — | — | US | disclosed |
| EP-0934320-A1 | NAPHTHYRIDINE DERIVATIVES | Novartis AG (CH) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998018796-A1 | NAPHTHYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 1998-05-07 | — | — | WO | disclosed |