Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6246256 | 0.86 | MAPT (0.58) | MMP13SLC22A8MAPTKDM4EHDAC1 | |
| SCHEMBL6517292 | 0.86 | MAPT (0.59) | MMP13SLC22A8MAPTMAPK1L3MBTL1 | |
| SCHEMBL7102887 | 0.85 | MMP13 (0.54) | MMP13SLC22A8MAPTMAPK1L3MBTL1 | |
| SCHEMBL7102983 | 0.85 | MMP13 (0.54) | MMP13SLC22A8MAPTMAPK1L3MBTL1 | |
| SCHEMBL7095851 | 0.84 | MMP13 (0.65) | MMP13SLC22A8MAPTMAPK1L3MBTL1 | |
| SCHEMBL6532934 | 0.83 | PPARG (0.56) | MMP13SLC22A8MAPTMAPK1L3MBTL1 | |
| SCHEMBL7100567 | 0.83 | MMP13 (0.56) | MMP13SLC22A8MAPTMAPK1L3MBTL1 | |
| SCHEMBL7101956 | 0.83 | MMP13 (0.54) | MMP13SLC22A8MAPTMAPK1L3MBTL1 | |
| SCHEMBL6234634 | 0.82 | MMP13 (0.58) | MMP13MAPTKDM4EHDAC1SMN1; SMN2 | |
| SCHEMBL7653589 | 0.81 | ALDH1A1 (0.49) | MMP13MAPTKDM4EHDAC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368324-A1 | QUINAZOLINES AS MMP-13 INHIBITORS | Warner-Lambert Company LLC (US) | 2003-12-10 | — | — | EP | claimed |
| WO-2002064572-A1 | QUINAZOLINES AS MMP-13 INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | claimed |