Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 4/20 | 0.53 |
| ▸ | SNCA | P37840 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL710299 | 1.00 | MAPT (0.66) | MAPTTRPA1NPC1RAB9AKDM4E | |
| SCHEMBL710153 | 0.90 | NPC1 (0.55) | MAPTTRPA1NPC1RAB9AKDM4E | |
| SCHEMBL710154 | 0.90 | NPC1 (0.55) | MAPTTRPA1NPC1RAB9AKDM4E | |
| SCHEMBL8782792 | 0.88 | MAOB (0.53) | MAPTTRPA1NPC1RAB9AKDM4E | |
| SCHEMBL14399195 | 0.87 | NQO2 (0.55) | MAPTTRPA1NPC1RAB9ACYP1A2 | |
| SCHEMBL28595722 | 0.84 | KMT2A (0.80) | MAPTNPC1RAB9AKDM4EHPGD | |
| SCHEMBL29419010 | 0.84 | KMT2A (0.80) | MAPTNPC1RAB9AKDM4EHPGD | |
| SCHEMBL16597820 | 0.81 | KDM4E (0.63) | MAPTTRPA1NPC1RAB9AKDM4E | |
| SCHEMBL16597578 | 0.81 | KDM4E (0.63) | MAPTTRPA1NPC1RAB9AKDM4E | |
| SCHEMBL19076166 | 0.81 | RELA (0.60) | MAPTNPC1RAB9ACYP1A2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110698391-B | Preparation method of heterocycle substituted alkyl sulfone or heterocycle substituted alkyl sulfonamide compound | 台州学院 | 2021-06-25 | — | — | CN | disclosed |
| CN-110698391-A | Preparation method of heterocycle substituted alkyl sulfone or heterocycle substituted alkyl sulfonamide compound | 台州学院 | 2020-01-17 | — | — | CN | disclosed |
| US-9868705-B2 | Tetra-aryl cyclobutane inhibitors of androgen receptor action for the treatment of hormone refractory cancer | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2018-01-16 | — | — | US | disclosed |
| US-20160229811-A1 | TETRA-ARYL CYCLOBUTANE INHIBITORS OF ANDROGEN RECEPTOR ACTION FOR THE TREATMENT OF HORMONE REFRACTORY CANCER | DUKE UNIVERSITY | 2016-08-11 | — | — | US | disclosed |
| WO-2015048246-A1 | TETRA-ARYL CYCLOBUTANE INHIBITORS OF ANDROGEN RECEPTOR ACTION FOR THE TREATMENT OF HORMONE REFRACTORY CANCER | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2015-04-02 | — | — | WO | disclosed |
| US-8124625-B2 | enhancing the expression of apoAI; prevention or therapy of dislipidemia | SHIONOGI & CO., LTD. (JP) | 2012-02-28 | — | — | US | disclosed |
| US-8053445-B2 | Utilities of olefin derivatives | SHIONOGI & CO., LTD. (JP) | 2011-11-08 | — | — | US | disclosed |
| US-20090036457-A1 | Utilities of olefin derivatives | YAMAMORI TERUO | 2009-02-05 | — | — | US | disclosed |
| US-20060058354-A1 | Conjugated aromatic compounds with a pyridine substituent | ALANINE ALEXANDER | 2006-03-16 | — | — | US | disclosed |
| US-20040242615-A1 | Utilities of olefin derivatives | SHIONOGI & CO., LTD. (JP) | 2004-12-02 | — | — | US | disclosed |
| US-3940486-A | Imidazole derivatives in the treatment of pain | CIBA-GEIGY CORPORATION (US) | 1976-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229811-A1 | TETRA-ARYL CYCLOBUTANE INHIBITORS OF ANDROGEN RECEPTOR ACTION FOR THE TREATMENT OF HORMONE REFRACTORY CANCER | AR, FSHR, ESRRB | MAPT 4421/4885TRPA1 4235/4885NPC1 3699/4885 |
| US-20040242615-A1 | Utilities of olefin derivatives | APOL1, NR1H2, APOB | MAPT 3896/4885TRPA1 2541/4885NPC1 19/4885 |
| US-20060058354-A1 | Conjugated aromatic compounds with a pyridine substituent | GRIN2B, GRIN3A, GRIN2C | MAPT 907/4885TRPA1 231/4885NPC1 804/4885 |
| US-20090036457-A1 | Utilities of olefin derivatives | APOL1, APOB, NR1H2 | MAPT 3909/4885TRPA1 2509/4885NPC1 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.