SCHEMBL7103025

SCHEMBL7103025

CCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCC2CC2)cc1

nearest known ligand 0.94

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 15/20 0.94
AGTR2 P50052 15/20 0.94

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8351241 0.97 AGTR2 (1.00) AGTR1AGTR2
SCHEMBL8348100 0.92 AGTR2 (1.00) AGTR1AGTR2
SCHEMBL7021272 0.90 AGTR2 (1.00) AGTR1AGTR2
SCHEMBL6544946 0.89 AGTR2 (1.00) AGTR1AGTR2
SCHEMBL7103027 0.89 AGTR2 (0.76) AGTR1AGTR2
SCHEMBL7026921 0.87 AGTR1 (0.83) AGTR1AGTR2
SCHEMBL8351247 0.87 AGTR1 (1.00) AGTR1AGTR2
SCHEMBL7101649 0.86 AGTR2 (0.71) AGTR1AGTR2
SCHEMBL8901703 0.86 AGTR2 (0.71) AGTR1AGTR2
SCHEMBL8976602 0.85 AGTR2 (1.00) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0560177-B1 Imidazole derivatives having biphenylsulphonylurea or biphenylsulfonylurethane side chains, process for their production and use thereof HOECHST AG (DE) 2003-01-08 EP disclosed
US-5604251-A Imidazole derivatives with a biphenylsulfonylurea or biphenylsulfonylurethane side chain and their use as angitensin II receptors HOECHST AKTIENGESELLSCHAFT (DE) 1997-02-18 US disclosed
EP-0560177-A1 Imidazole derivatives having biphenylsulphonylurea or biphenylsulfonylurethane side chains, process for their production and use thereof HOECHST AKTIENGESELLSCHAFT (DE) 1993-09-15 EP disclosed