Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 16/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 16/20 | 0.46 |
| ▸ | PDK3 | Q15120 | 16/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 16/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27569048 | 0.85 | PDK1 (0.67) | PDK1PDK2PDK3PDK4ABCB11 | |
| SCHEMBL27569049 | 0.85 | PDK1 (0.67) | PDK1PDK2PDK3PDK4ABCB11 | |
| SCHEMBL28091743 | 0.78 | PDK1 (0.69) | PDK1PDK2PDK3PDK4NPC1 | |
| SCHEMBL618106 | 0.76 | PDK1 (0.70) | PDK1PDK2PDK3PDK4TRPV1 | |
| SCHEMBL8116203 | 0.76 | KMT2A (0.56) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL2069741 | 0.76 | MEN1 (0.55) | PDK1PDK2PDK3PDK4CA1 | |
| SCHEMBL7880575 | 0.75 | PDK1 (0.68) | PDK1PDK2PDK3PDK4TRPV1 | |
| SCHEMBL15072455 | 0.75 | MAPK1 (0.55) | PDK1PDK2PDK3PDK4NPC1 | |
| SCHEMBL9384576 | 0.75 | PDK1 (0.50) | PDK1PDK2PDK3PDK4CA1 | |
| SCHEMBL6747082 | 0.74 | CA12 (0.51) | NPC1RAB9ACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043308-B1 | PHENYLAMINOALKYLCARBOXYLIC ACID DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | KISSEI PHARMACEUTICAL (JP) | 2003-09-24 | — | — | EP | disclosed |
| US-6353025-B1 | COMPOUNDS AS DRUGS | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2002-03-05 | — | — | US | disclosed |
| EP-1043308-A1 | PHENYLAMINOALKYLCARBOXYLIC ACID DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | Kissei Pharmaceutical Co., Ltd. (JP) | 2000-10-11 | — | — | EP | disclosed |