Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.44 |
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
| ▸ | MASP2 | O00187 | 1/20 | 0.31 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.30 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7101063 | 0.93 | ADAM17 (0.39) | ADAM17 | |
| SCHEMBL7100106 | 0.78 | ADAM17 (0.40) | ADAM17 | |
| Hydrochloric Acid SCHEMBL7105152 | 0.78 | ADAM17 (0.40) | ADAM17 | |
| SCHEMBL6939564 | 0.76 | ADAM17 (0.40) | ADAM17CTSCMASP2GRIK1GRIK2 | |
| SCHEMBL6940773 | 0.76 | ADAM17 (0.40) | ADAM17CTSCMASP2GRIK1GRIK2 | |
| SCHEMBL7104725 | 0.75 | ADAM17 (0.39) | ADAM17MASP2 | |
| Hydrochloric Acid SCHEMBL7104764 | 0.74 | ADAM17 (0.39) | ADAM17MASP2 | |
| Hydrochloric Acid SCHEMBL6982510 | 0.73 | ADAM17 (0.39) | ADAM17CTSCMASP2GRIK1GRIK2 | |
| SCHEMBL6981776 | 0.72 | ADAM17 (0.39) | ADAM17CTSCMASP2GRIK1GRIK2 | |
| Hydrochloric Acid SCHEMBL6985991 | 0.72 | ADAM17 (0.39) | ADAM17CTSCMASP2GRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133471-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-09-17 | — | — | EP | claimed |
| EP-1133471-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-09-19 | — | — | EP | claimed |
| WO-2000032570-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-08 | — | — | WO | claimed |
| EP-1133471-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-09-17 | — | — | EP | disclosed |
| EP-1133471-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-09-19 | — | — | EP | disclosed |
| US-6265446-B1 | ANTIINFLAMMATORY AGENTS; AUTOIMMUNE DISEASES | HOFFMANN-LA ROCHE INC.. | 2001-07-24 | — | — | US | disclosed |
| WO-2000032570-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-08 | — | — | WO | disclosed |