Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.51 |
| ▸ | FPR2 | P25090 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.46 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.46 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.46 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | CTSD | P07339 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7099462 | 0.91 | KMT2A (0.60) | KMT2AFPR2PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL7099460 | 0.91 | KMT2A (0.60) | KMT2AFPR2PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL7102822 | 0.91 | KMT2A (0.49) | KMT2AADAMTS5PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL7104049 | 0.90 | KMT2A (0.49) | KMT2AADAMTS5PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL7104122 | 0.88 | MMP8 (0.55) | PLAAT3PLAAT5PLAAT2PLAAT4NPC1 | |
| SCHEMBL7099381 | 0.88 | MMP8 (0.55) | PLAAT3PLAAT5PLAAT2PLAAT4NPC1 | |
| SCHEMBL7098301 | 0.88 | ADAMTS5 (0.54) | KMT2AADAMTS5CNR1PLAAT3PLAAT5 | |
| SCHEMBL7104238 | 0.88 | KMT2A (0.48) | KMT2ATAAR1NPC1GAARAB9A | |
| SCHEMBL7098639 | 0.87 | LMNA (0.53) | KMT2APLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL7101188 | 0.86 | KMT2A (0.45) | KMT2APLAAT3PLAAT5PLAAT2PLAAT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140818-B1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | AVENTIS PHARMA INC (US) | 2003-09-10 | — | — | EP | disclosed |
| US-6329550-B1 | FOR THERAPY OF EMPHYSEMA, OSTEOPOROSIS, RHEUMATOID ARTHRITIS AND NEOPLASTIC DISEASES | AVENTIS PHARMACEUTICALS INC. | 2001-12-11 | — | — | US | disclosed |