SCHEMBL7103804

SCHEMBL7103804

CCOc1cc([C@@H]2CCCN(NC)C2)cnc1Br

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 3/20 0.41
CHRNA4 P43681 3/20 0.41
PROKR1 Q8TCW9 5/20 0.35
DRD2 P14416 3/20 0.34
DRD1 P21728 2/20 0.34
DRD4 P21917 2/20 0.34
DRD5 P21918 2/20 0.34
DRD3 P35462 2/20 0.34
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
HPGD P15428 1/20 0.33
TSHR P16473 1/20 0.33
CASP1 P29466 1/20 0.33
CASP7 P55210 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
HSD17B10 Q99714 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33
PDGFRB P09619 1/20 0.32
PDGFRA P16234 1/20 0.32
DGAT2 Q96PD7 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7102514 1.00 CHRNB2 (0.41) CHRNB2CHRNA4PROKR1DRD2DRD1
SCHEMBL7101803 0.97 CHRNB2 (0.41) CHRNB2CHRNA4PROKR1DRD2DRD1
SCHEMBL7103730 0.97 CHRNB2 (0.41) CHRNB2CHRNA4PROKR1DRD2DRD1
SCHEMBL7098317 0.93 CHRNB2 (0.40) CHRNB2CHRNA4PROKR1KDM4EALDH1A1
SCHEMBL7098503 0.93 CHRNB2 (0.40) CHRNB2CHRNA4PROKR1KDM4EALDH1A1
SCHEMBL7098388 0.91 CHRNB2 (0.41) CHRNB2CHRNA4PROKR1KDM4EALDH1A1
SCHEMBL7103751 0.91 CHRNB2 (0.41) CHRNB2CHRNA4PROKR1KDM4EALDH1A1
SCHEMBL7103964 0.81 PROKR1 (0.33) PROKR1DRD2DRD1DRD4DRD5
SCHEMBL7100533 0.81 SLC6A2 (0.36) CHRNB2CHRNA4PROKR1DRD2DRD1
SCHEMBL7102550 0.81 PROKR1 (0.33) PROKR1DRD2DRD1DRD4DRD5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2003500402-A 2003-01-07 JP claimed
EP-1178982-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2002-02-13 EP claimed
WO-2000071534-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2000-11-30 WO claimed
EP-1178982-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2002-02-13 EP disclosed
WO-2000071534-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2000-11-30 WO disclosed