Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.56 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.56 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.56 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.56 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 6/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4382926 | 0.88 | NOTUM (0.42) | GRIA1GRIA2GRIA3GRIA4MAP2K1 | |
| SCHEMBL4929162 | 0.74 | GRIA1 (0.55) | GRIA1GRIA2GRIA3GRIA4OR51E2 | |
| SCHEMBL6781370 | 0.72 | GRIA1 (1.00) | GRIA1GRIA2GRIA3GRIA4PARP1 | |
| SCHEMBL706419 | 0.71 | — | — | |
| SCHEMBL6015897 | 0.70 | GRIA1 (0.53) | GRIA1GRIA2GRIA3GRIA4KDM4E | |
| SCHEMBL917625 | 0.69 | PARP1 (0.43) | GRIA1GRIA2GRIA3GRIA4KDM4E | |
| SCHEMBL4723110 | 0.69 | PARP1 (0.47) | GRIA1GRIA2GRIA3GRIA4MAPT | |
| SCHEMBL5655667 | 0.69 | NOTUM (0.41) | GRIA1GRIA2GRIA3GRIA4MAP2K1 | |
| SCHEMBL25365116 | 0.68 | PARP1 (0.42) | GRIA1GRIA2GRIA3GRIA4KDM4E | |
| SCHEMBL31208007 | 0.68 | PARP1 (0.42) | GRIA1GRIA2GRIA3GRIA4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5391554-A | Antitumor agent | WARNER-LAMBERT COMPANY (US) | 1995-02-21 | — | — | US | claimed |
| WO-1994005664-A1 | NAPHTHYRIDINES AS POTENTIATORS OF LETHAL EFFECTS OF RADIATION ON TUMOUR CELLS | WARNER-LAMBERT COMPANY (US) | 1994-03-17 | — | — | WO | claimed |
| EP-1307453-A2 | DIHYDRONAPHTHYRIDINE- AND DIHYDROPYRROLOPYRIDINE-DERIVATED COMPOUNDS AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2003-05-07 | — | — | EP | disclosed |
| US-20020099070-A1 | Dihydronaphthyridine potassium channel openers | ABBOTT LABORATORIES | 2002-07-25 | — | — | US | disclosed |
| WO-2002010164-A2 | DIHYDRONAPHTHYRIDINE- AND DIHYDROPYRROLOPYRIDINE-DERIVATED COMPOUNDS AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-02-07 | — | — | WO | disclosed |
| US-5391554-A | Antitumor agent | WARNER-LAMBERT COMPANY (US) | 1995-02-21 | — | — | US | disclosed |
| WO-1994005664-A1 | NAPHTHYRIDINES AS POTENTIATORS OF LETHAL EFFECTS OF RADIATION ON TUMOUR CELLS | WARNER-LAMBERT COMPANY (US) | 1994-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020099070-A1 | Dihydronaphthyridine potassium channel openers | KCNH1, KCNN1, KCNJ2 | GRIA1 503/4885GRIA2 1093/4885GRIA3 498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.