Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | FPR2 | P25090 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.50 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.50 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.50 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7943506 | 0.88 | SMN1; SMN2 (0.51) | SMN1; SMN2TAAR1ALDH1A1KMT2AGLA | |
| Trifluoroacetic Acid SCHEMBL7103734 | 0.84 | MLYCD (0.54) | KMT2ANPC1RAB9APLAAT3PLAAT5 | |
| Trifluoroacetic Acid SCHEMBL5072989 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2TAAR1ALDH1A1KMT2AGLA | |
| SCHEMBL13073347 | 0.80 | KMT2A (0.63) | SMN1; SMN2TAAR1ALDH1A1KMT2AFPR2 | |
| SCHEMBL140038 | 0.79 | SMN1; SMN2 (0.67) | SMN1; SMN2TAAR1ALDH1A1KMT2AGLA | |
| Trifluoroacetic Acid SCHEMBL3665235 | 0.79 | SMN1; SMN2 (0.52) | SMN1; SMN2TAAR1ALDH1A1KMT2AGLA | |
| SCHEMBL11713117 | 0.79 | SMN1; SMN2 (0.58) | SMN1; SMN2TAAR1ALDH1A1KMT2AGLA | |
| SCHEMBL6977801 | 0.79 | SMN1; SMN2 (0.58) | SMN1; SMN2TAAR1ALDH1A1KMT2AGLA | |
| SCHEMBL7943508 | 0.79 | SMN1; SMN2 (0.49) | SMN1; SMN2TAAR1ALDH1A1KMT2AGLA | |
| SCHEMBL7904484 | 0.78 | SMN1; SMN2 (0.69) | SMN1; SMN2TAAR1ALDH1A1KMT2AGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140818-B1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | AVENTIS PHARMA INC (US) | 2003-09-10 | — | — | EP | disclosed |
| US-6329550-B1 | FOR THERAPY OF EMPHYSEMA, OSTEOPOROSIS, RHEUMATOID ARTHRITIS AND NEOPLASTIC DISEASES | AVENTIS PHARMACEUTICALS INC. | 2001-12-11 | — | — | US | disclosed |