Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL7103734

NC(C(=O)NCCc1ccccc1)C(=O)NCCc1ccccc1.O=C(O)C(F)(F)F

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MLYCD O95822 2/20 0.54
TACR1 P25103 1/20 0.52
POLB P06746 1/20 0.51
KMT2A Q03164 2/20 0.50
HDAC3 O15379 1/20 0.50
HDAC4 P56524 1/20 0.50
HDAC1 Q13547 1/20 0.50
HDAC6 Q9UBN7 1/20 0.50
PLAAT3 P53816 1/20 0.50
PLAAT5 Q96KN8 1/20 0.50
PLAAT2 Q9NWW9 1/20 0.50
PLAAT4 Q9UL19 1/20 0.50
CA12 O43570 1/20 0.49
CA2 P00918 1/20 0.49
CA9 Q16790 1/20 0.49
NPC1 O15118 2/20 0.48
RAB9A P51151 2/20 0.48
CYP2D6 P10635 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL7101439 0.91 CYP2D6 (0.60) MLYCDTACR1POLBKMT2ANPC1
Trifluoroacetic Acid SCHEMBL10424061 0.86 KMT2A (0.50) MLYCDPOLBKMT2AHDAC3HDAC4
Trifluoroacetic Acid SCHEMBL7101192 0.84 MMP8 (0.53) TACR1KMT2AHDAC3HDAC4HDAC1
Trifluoroacetic Acid SCHEMBL7104230 0.84 SMN1; SMN2 (0.56) KMT2APLAAT3PLAAT5PLAAT2PLAAT4
SCHEMBL13073729 0.81 PLAAT3 (0.60) MLYCDTACR1PLAAT3PLAAT5PLAAT2
SCHEMBL14861105 0.80 CA12 (0.61) POLBKMT2ACA12CA2
SCHEMBL6961215 0.80 CA12 (0.61) POLBKMT2ACA12CA2
SCHEMBL13073331 0.80 CA12 (0.61) POLBKMT2ACA12CA2
Trifluoroacetic Acid SCHEMBL2213601 0.79 HDAC3 (0.57) MLYCDHDAC3HDAC4HDAC1HDAC6
Hydrochloric Acid SCHEMBL7759019 0.78 CA12 (0.60) POLBKMT2ACA12CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1140818-B1 AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE AVENTIS PHARMA INC (US) 2003-09-10 EP disclosed
US-6329550-B1 FOR THERAPY OF EMPHYSEMA, OSTEOPOROSIS, RHEUMATOID ARTHRITIS AND NEOPLASTIC DISEASES AVENTIS PHARMACEUTICALS INC. 2001-12-11 US disclosed
EP-1140818-A1 AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE Aventis Pharmaceuticals Inc. (US) 2001-10-10 EP disclosed
WO-2000040552-A1 AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE AVENTIS PHARMACEUTICALS INC. (US) 2000-07-13 WO disclosed