SCHEMBL7104294

SCHEMBL7104294

COc1ccc(C=CCCC(C#N)C(=O)O)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIK1 P39086 1/20 0.49
GRIK2 Q13002 1/20 0.49
THRB P10828 1/20 0.47
ATM Q13315 1/20 0.47
GSK3B P49841 2/20 0.46
F3 P13726 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
RAB9A P51151 2/20 0.44
NPC1 O15118 1/20 0.44
LMNA P02545 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
PTGER4 P35408 1/20 0.43
PTGER3 P43115 1/20 0.43
PTGER2 P43116 1/20 0.43
BACE1 P56817 1/20 0.43
TAS1R3 Q7RTX0 2/20 0.42
TAS1R1 Q7RTX1 2/20 0.42
LTB4R Q15722 1/20 0.42
LTB4R2 Q9NPC1 1/20 0.42
BCHE P06276 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27993003 0.83 GRIK1 (0.56) GRIK1GRIK2THRBATMGSK3B
SCHEMBL27993002 0.75 GSK3B (0.54) GRIK1GRIK2THRBATMGSK3B
SCHEMBL16710517 0.74 NPC1 (0.65) GRIK1GRIK2THRBATMGSK3B
SCHEMBL10667891 0.73 LDHA (0.65)
SCHEMBL11553950 0.72 GSK3B (0.47) GRIK1GRIK2THRBATMGSK3B
SCHEMBL10419453 0.72 LDHA (0.48) TDP1LTB4R
SCHEMBL11553952 0.72 GSK3B (0.47) GRIK1GRIK2THRBATMGSK3B
SCHEMBL8862104 0.72 LTB4R (0.65) GRIK1GRIK2THRBATMGSK3B
SCHEMBL7999191 0.72 LTB4R (0.65) GRIK1GRIK2THRBATMGSK3B
SCHEMBL8079926 0.72 KDM4E (0.44) GRIK1GRIK2GSK3BSMN1; SMN2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0620929-B1 PHOTOGRAPHIC DISPERSION EASTMAN KODAK CO (US) 2003-10-01 EP claimed
US-5468604-A Particle growth inhibition EASTMAN KODAK COMPANY (US) 1995-11-21 US claimed
EP-0620929-A1 PHOTOGRAPHIC DISPERSION EASTMAN KODAK COMPANY (US) 1994-10-26 EP claimed
WO-1994011784-A1 PHOTOGRAPHIC DISPERSION EASTMAN KODAK COMPANY (US) 1994-05-26 WO claimed
EP-0620929-B1 PHOTOGRAPHIC DISPERSION EASTMAN KODAK CO (US) 2003-10-01 EP disclosed
US-6143484-A ADDING TO EMULSION CONTAINING SILVER HALIDE PARTICLES SUFFICIENT AMOUNT OF SURFACTANT TO PASSIFY SURFACES OF SILVER HALIDE PARTICLES EASTMAN KODAK COMPANY (US) 2000-11-07 US disclosed
US-5468604-A Particle growth inhibition EASTMAN KODAK COMPANY (US) 1995-11-21 US disclosed
EP-0620929-A1 PHOTOGRAPHIC DISPERSION EASTMAN KODAK COMPANY (US) 1994-10-26 EP disclosed
WO-1994011784-A1 PHOTOGRAPHIC DISPERSION EASTMAN KODAK COMPANY (US) 1994-05-26 WO disclosed