Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 5/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 2/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.35 |
| ▸ | LONP1 | P36776 | 3/20 | 0.35 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.35 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.35 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.35 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.35 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.35 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.35 |
| ▸ | PSMA4 | P25789 | 2/20 | 0.35 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.35 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.35 |
| ▸ | PSMA5 | P28066 | 2/20 | 0.35 |
| ▸ | PSMB4 | P28070 | 2/20 | 0.35 |
| ▸ | PSMB6 | P28072 | 2/20 | 0.35 |
| ▸ | PSMB10 | P40306 | 2/20 | 0.35 |
| ▸ | PSMB3 | P49720 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7109870 | 0.91 | CNR1 (0.44) | CNR1CNR2CCR1PSMB5LONP1 | |
| SCHEMBL7655289 | 0.84 | ALDH1A1 (0.44) | CNR1CNR2MME | |
| SCHEMBL7109282 | 0.83 | CNR1 (0.42) | CNR1CNR2CCR1PSMB5LONP1 | |
| SCHEMBL7663610 | 0.79 | P2RX7 (0.44) | CNR1 | |
| SCHEMBL8060452 | 0.78 | ALDH1A1 (0.42) | CNR1MME | |
| SCHEMBL7105347 | 0.77 | CNR1 (0.46) | CNR1CNR2MMEAKR1B1 | |
| SCHEMBL7654698 | 0.76 | KDM4E (0.44) | CCR1 | |
| SCHEMBL7110167 | 0.75 | ALDH1A1 (0.38) | CNR2 | |
| SCHEMBL18130879 | 0.74 | CNR2 (0.55) | CNR1CNR2 | |
| SCHEMBL18130962 | 0.74 | CNR2 (0.55) | CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| EP-1001944-A1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | Aventis Pharma S.A. (FR) | 2000-05-24 | — | — | EP | claimed |
| WO-1999003844-A1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1999-01-28 | — | — | WO | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |