Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 6/20 | 0.44 |
| ▸ | CCR1 | P32246 | 3/20 | 0.37 |
| ▸ | LONP1 | P36776 | 5/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.36 |
| ▸ | PSMB11 | A5LHX3 | 3/20 | 0.36 |
| ▸ | PSMA7 | O14818 | 3/20 | 0.36 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.36 |
| ▸ | PSMA1 | P25786 | 3/20 | 0.36 |
| ▸ | PSMA2 | P25787 | 3/20 | 0.36 |
| ▸ | PSMA3 | P25788 | 3/20 | 0.36 |
| ▸ | PSMA4 | P25789 | 3/20 | 0.36 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.36 |
| ▸ | PSMB9 | P28065 | 3/20 | 0.36 |
| ▸ | PSMA5 | P28066 | 3/20 | 0.36 |
| ▸ | PSMB4 | P28070 | 3/20 | 0.36 |
| ▸ | PSMB6 | P28072 | 3/20 | 0.36 |
| ▸ | PSMB10 | P40306 | 3/20 | 0.36 |
| ▸ | PSMB3 | P49720 | 3/20 | 0.36 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.36 |
| ▸ | PSMA6 | P60900 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7109282 | 0.94 | CNR1 (0.42) | CNR1CCR1LONP1PSMB5PSMB11 | |
| SCHEMBL7104649 | 0.91 | CNR1 (0.44) | CNR1CCR1LONP1PSMB5PSMB11 | |
| SCHEMBL7106764 | 0.81 | CNR1 (0.46) | CNR1CNR2AKR1B1S1PR3 | |
| SCHEMBL7104658 | 0.79 | SMN1; SMN2 (0.35) | CNR1PSMB5PSMB11PSMA7PSMB1 | |
| SCHEMBL7663610 | 0.78 | P2RX7 (0.44) | CNR1KDM4EGAA | |
| SCHEMBL7655289 | 0.77 | ALDH1A1 (0.44) | CNR1CNR2KDM4ENPC1RAB9A | |
| SCHEMBL8060452 | 0.76 | ALDH1A1 (0.42) | CNR1KDM4ENPC1RAB9A | |
| SCHEMBL7654698 | 0.75 | KDM4E (0.44) | CCR1KDM4EGAA | |
| SCHEMBL7109193 | 0.75 | ICAM1 (0.40) | CNR2KDM4E | |
| SCHEMBL7108034 | 0.74 | CNR1 (0.44) | CNR1CNR2AKR1B1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | disclosed |
| EP-1001944-A1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | Aventis Pharma S.A. (FR) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999003844-A1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1999-01-28 | — | — | WO | disclosed |