Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD1 | P21728 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | DRD5 | P21918 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7485261 | 0.96 | PROKR1 (0.35) | CHRNB2CHRNA4DRD2DRD1DRD4 | |
| SCHEMBL7487692 | 0.96 | PROKR1 (0.35) | CHRNB2CHRNA4DRD2DRD1DRD4 | |
| SCHEMBL7103400 | 0.92 | CHRNB2 (0.35) | CHRNB2CHRNA4 | |
| SCHEMBL7488149 | 0.89 | CHRNB2 (0.39) | CHRNB2CHRNA4 | |
| SCHEMBL7098495 | 0.83 | CHRNB2 (0.42) | CHRNB2CHRNA4PROKR1 | |
| SCHEMBL7098400 | 0.80 | ALDH1A1 (0.41) | CHRNB2CHRNA4PROKR1 | |
| SCHEMBL7103962 | 0.80 | ALDH1A1 (0.41) | CHRNB2CHRNA4PROKR1 | |
| SCHEMBL7105555 | 0.78 | ALDH1A1 (0.39) | CHRNB2CHRNA4PROKR1 | |
| SCHEMBL7101906 | 0.78 | ALDH1A1 (0.39) | CHRNB2CHRNA4PROKR1 | |
| SCHEMBL7100533 | 0.77 | SLC6A2 (0.36) | CHRNB2CHRNA4DRD2DRD1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003500402-A | — | — | 2003-01-07 | — | — | JP | claimed |
| EP-1178982-A1 | HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS | ABBOTT LABORATORIES (US) | 2002-02-13 | — | — | EP | claimed |
| WO-2000071534-A1 | HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS | ABBOTT LABORATORIES (US) | 2000-11-30 | — | — | WO | claimed |