Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 5/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD5 | P21918 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7485261 | 1.00 | PROKR1 (0.35) | PROKR1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL7105311 | 0.96 | CHRNB2 (0.39) | PROKR1CHRNB2CHRNA4DRD2DRD1 | |
| SCHEMBL7103400 | 0.90 | CHRNB2 (0.35) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNA4 | |
| SCHEMBL7488149 | 0.85 | CHRNB2 (0.39) | CHRNB2CHRNA4KDM4EGLAHTT | |
| SCHEMBL7098400 | 0.84 | ALDH1A1 (0.41) | PROKR1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL7103962 | 0.84 | ALDH1A1 (0.41) | PROKR1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL7098495 | 0.80 | CHRNB2 (0.42) | PROKR1CHRNB2CHRNA4 | |
| SCHEMBL7098837 | 0.79 | ALDH1A1 (0.44) | PROKR1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL7098418 | 0.79 | ALDH1A1 (0.44) | PROKR1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL7102607 | 0.78 | SLC6A2 (0.41) | PROKR1SLC6A2SLC6A4SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178982-A1 | HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS | ABBOTT LABORATORIES (US) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000071534-A1 | HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS | ABBOTT LABORATORIES (US) | 2000-11-30 | — | — | WO | disclosed |