Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 5/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13211502 | 0.64 | GSK3B (0.47) | GSK3BGSK3APOLBCYP3A4SLC6A2 | |
| SCHEMBL2911529 | 0.63 | MAPT (0.45) | GSK3BGSK3ATDP1ALDH1A1 | |
| SCHEMBL7105334 | 0.61 | SLC6A2 (0.33) | GSK3BGSK3AHTR2CTDP1KDM4E | |
| SCHEMBL3598377 | 0.60 | DPP4 (0.43) | CNR1TDP1CYP3A4CYP2C19MCHR1 | |
| SCHEMBL3598863 | 0.60 | HTT (0.43) | CNR1TDP1CYP3A4CYP2C19MCHR1 | |
| SCHEMBL27559805 | 0.59 | POLB (0.50) | CNR1KDM4EPOLB | |
| SCHEMBL157609 | 0.59 | SLC6A2 (0.56) | ALDH1A1POLBSLC6A2SLC6A4 | |
| SCHEMBL21424922 | 0.58 | DRD2 (0.57) | ALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL20200690 | 0.57 | HRH3 (0.42) | — | |
| SCHEMBL27538115 | 0.57 | CYP2A13 (0.55) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |