Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 4/20 | 0.31 |
| ▸ | DRD3 | P35462 | 4/20 | 0.31 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7105342 | 0.61 | GSK3B (0.43) | SLC6A2SLC6A4KDM4EALDH1A1POLB | |
| SCHEMBL157609 | 0.58 | SLC6A2 (0.56) | SLC6A2SLC6A4ALDH1A1POLBDRD2 | |
| SCHEMBL13211502 | 0.58 | GSK3B (0.47) | SLC6A2SLC6A4POLBGSK3BGSK3A | |
| SCHEMBL21424922 | 0.58 | DRD2 (0.57) | SLC6A2SLC6A4ALDH1A1DRD2DRD3 | |
| SCHEMBL11491115 | 0.56 | L3MBTL1 (0.51) | ALDH1A1DRD2KMT2AHTR1AHTR7 | |
| SCHEMBL4922025 | 0.54 | ALOX15 (0.32) | — | |
| SCHEMBL21594995 | 0.53 | L3MBTL1 (0.49) | SLC6A2SLC6A4KMT2A | |
| SCHEMBL5740932 | 0.53 | AHR (0.55) | DRD2DRD3HTR7HTR2C | |
| SCHEMBL14447297 | 0.52 | ACHE (0.43) | DRD2DRD3KCNH2HRH3 | |
| SCHEMBL4808962 | 0.52 | ALOX15 (0.32) | TDP1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |