SCHEMBL7105867

SCHEMBL7105867

C=CC[Si](CC=C)(CC=C)OS(=O)(=O)Cl

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2059573 0.80 CA2 (0.30)
SCHEMBL2059582 0.76
SCHEMBL10570362 0.76
SCHEMBL8149462 0.74
SCHEMBL3159776 0.71
SCHEMBL168925 0.71
SCHEMBL7041191 0.67
SCHEMBL9302567 0.67
SCHEMBL3266926 0.66
SCHEMBL2059584 0.66 ALDH1A1 (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6727279-B2 CENTRAL NERVOUS SYSTEM DISORDERS BAYER AKTIENGESELLSCHAFT (DE) 2004-04-27 US claimed
US-20030073727-A1 Novel arylsulphonamides and analogues MITTENDORF JOACHIM (DE) 2003-04-17 US claimed
EP-0747350-B1 PROCESS FOR PRODUCING BIS(4-ALKYLTHIOPHENYL) DISULFIDE TORAY INDUSTRIES (JP) 2003-03-19 EP claimed
EP-0966436-B1 ARYL SULFONAMIDES AND ANALOGUES THEREOF AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES BAYER AG (DE) 2002-12-11 EP claimed
US-6469054-B1 PROPHYLAXIS AND TREATMENT OF NEURODEGENERATIVE DISORDERS, IN PARTICULAR FOR THE TREATMENT OF CEREBRAL APOPLEXY, CRANIOCEREBRAL TRAUMA, PAIN AND SPASTICITY BAYER AKTIENGESELLSHAFT (DE) 2002-10-22 US claimed
US-20020072529-A1 Arylsulfonamides and analogues BAYER INTELLECTUAL PROPERTY GMBH (DE) 2002-06-13 US claimed
EP-0747350-A1 PROCESS FOR PRODUCING BIS(4-ALKYLTHIOPHENYL) DISULFIDE TORAY INDUSTRIES, INC. (JP) 1996-12-11 EP claimed
US-6727279-B2 CENTRAL NERVOUS SYSTEM DISORDERS BAYER AKTIENGESELLSCHAFT (DE) 2004-04-27 US disclosed
US-6573278-B2 For therapy and prophylaxis of cerebral apoplexy and craniocerebral trauma BAYER AKTIENGESELLSCHAFT (DE) 2003-06-03 US disclosed
US-20030073727-A1 Novel arylsulphonamides and analogues MITTENDORF JOACHIM (DE) 2003-04-17 US disclosed
US-6545050-B1 Prophylaxis and treatment of neurodegenerative disorders, in particular for the treatment of cerebral apoplexy, craniocerebral trauma, pain and spasticity. BAYER AKTIENGESELLSCHAFT (DE) 2003-04-08 US disclosed
EP-0747350-B1 PROCESS FOR PRODUCING BIS(4-ALKYLTHIOPHENYL) DISULFIDE TORAY INDUSTRIES (JP) 2003-03-19 EP disclosed
US-6469054-B1 PROPHYLAXIS AND TREATMENT OF NEURODEGENERATIVE DISORDERS, IN PARTICULAR FOR THE TREATMENT OF CEREBRAL APOPLEXY, CRANIOCEREBRAL TRAUMA, PAIN AND SPASTICITY BAYER AKTIENGESELLSHAFT (DE) 2002-10-22 US disclosed
US-20020072529-A1 Arylsulfonamides and analogues BAYER INTELLECTUAL PROPERTY GMBH (DE) 2002-06-13 US disclosed
US-6262112-B1 1-(4,4,4-TRIFLUOROBUTYLSULPHONYLOXY)-3-(2-(HYDROXYMETHYL)INDAN -4-YLOXY)-BENZENE BAYER AKTIENGESELLSCHAFT (DE) 2001-07-17 US disclosed
US-5986143-A Method of producing bis(4-alkylthiophenyl) disulfides TORAY INDUSTRIES, INC. (JP) 1999-11-16 US disclosed
EP-0747350-A1 PROCESS FOR PRODUCING BIS(4-ALKYLTHIOPHENYL) DISULFIDE TORAY INDUSTRIES, INC. (JP) 1996-12-11 EP disclosed