Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | PPARA | Q07869 | 6/20 | 0.48 |
| ▸ | PPARG | P37231 | 5/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | CTSS | P25774 | 2/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7105931 | 1.00 | TSHR (0.55) | TSHRTP53PPARAPPARGATM | |
| SCHEMBL7097578 | 0.87 | GABRB1 (0.54) | TSHRTP53PPARAPPARGATM | |
| SCHEMBL7097577 | 0.87 | GABRB1 (0.54) | TSHRTP53PPARAPPARGATM | |
| SCHEMBL9544071 | 0.86 | PPARA (0.46) | TSHRTP53PPARAPPARGATM | |
| SCHEMBL9544068 | 0.86 | PPARA (0.46) | TSHRTP53PPARAPPARGATM | |
| SCHEMBL30496988 | 0.80 | ATM (0.48) | TSHRTP53PPARAPPARGATM | |
| SCHEMBL30158979 | 0.79 | TSHR (0.69) | TSHRTP53RECQLCYP2D6ALDH1A1 | |
| SCHEMBL7105585 | 0.78 | CTSK (0.43) | PPARAPPARGATMCYP2D6CTSK | |
| SCHEMBL7105576 | 0.78 | CTSK (0.43) | PPARAPPARGATMCYP2D6CTSK | |
| SCHEMBL7099862 | 0.77 | PPARA (0.58) | PPARAPPARGATMPPARDCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0990640-B1 | Beta-Hydroxyaspartic acid derivatives | SUNTORY LTD (JP) | 2003-01-22 | — | — | EP | disclosed |
| EP-0844234-B1 | Beta-hydroxyaspartic acid derivatives | SUNTORY LTD (JP) | 2002-03-06 | — | — | EP | disclosed |
| US-6147113-A | ADMINISTERING TO TREAT NERVOUS SYSTEM AND BRAIN DISORDERS; GLUTAMATE UPTAKE INHIBITORS | SUNTORY LIMITED (JP) | 2000-11-14 | — | — | US | disclosed |
| EP-0990640-A2 | Beta-Hydroxyaspartic acid derivatives | SUNTORY LIMITED (JP) | 2000-04-05 | — | — | EP | disclosed |
| EP-0948962-A2 | Beta-hydroxyaspartic acid derivatives | SUNTORY LIMITED (JP) | 1999-10-13 | — | — | EP | disclosed |
| EP-0844234-A2 | Beta-hydroxyaspartic acid derivatives | SUNTORY LIMITED (JP) | 1998-05-27 | — | — | EP | disclosed |