Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 | P13612 | 13/20 | 0.44 |
| ▸ | ITGB1 | P05556 | 12/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7106166 | 0.88 | ITGB1 (0.45) | ITGA4ITGB1 | |
| SCHEMBL4671791 | 0.88 | ITGA4 (0.47) | ITGA4ITGB1CHEK1LPAR1MEN1 | |
| SCHEMBL4671784 | 0.88 | ITGA4 (0.47) | ITGA4ITGB1CHEK1LPAR1MEN1 | |
| SCHEMBL7382803 | 0.88 | ITGB1 (0.45) | ITGA4ITGB1ATM | |
| SCHEMBL1817892 | 0.88 | ITGB1 (0.45) | ITGA4ITGB1ATM | |
| SCHEMBL1825903 | 0.88 | ITGB1 (0.45) | ITGA4ITGB1ATM | |
| SCHEMBL6165813 | 0.85 | ITGA4 (0.45) | ITGA4ITGB1CHEK1LPAR1MEN1 | |
| Tromethamine SCHEMBL1820966 | 0.83 | ITGB1 (0.41) | ITGA4ITGB1 | |
| SCHEMBL7101082 | 0.81 | ITGB1 (0.49) | ITGA4ITGB1 | |
| SCHEMBL7102059 | 0.81 | ITGB1 (0.49) | ITGA4ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183241-B1 | SPIROIMIDAZOLIDINE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM | AVENTIS PHARMA GMBH (DE) | 2003-09-17 | — | — | EP | disclosed |
| US-6399643-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-06-04 | — | — | US | disclosed |
| EP-1183241-A1 | SPIROIMIDAZOLIDINE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM | Aventis Pharma Deutschland GmbH (DE) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069831-A1 | SPIROIMIDAZOLIDINE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-23 | — | — | WO | disclosed |