Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PNP | P00491 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655871 | 0.84 | P4HTM (0.38) | KMT2APNPSCN9ASCN10A | |
| SCHEMBL7106490 | 0.84 | MEN1 (0.36) | MEN1KMT2ACNR1 | |
| SCHEMBL7104663 | 0.83 | CNR1 (0.32) | CNR1 | |
| SCHEMBL7107240 | 0.83 | MEN1 (0.35) | MEN1KMT2ACNR1 | |
| SCHEMBL7109261 | 0.81 | MLYCD (0.31) | — | |
| SCHEMBL7655284 | 0.79 | CYP1A2 (0.39) | MEN1KMT2ACNR1 | |
| SCHEMBL7654546 | 0.76 | KMT2A (0.38) | MEN1KMT2A | |
| SCHEMBL7108522 | 0.76 | SMO (0.40) | MEN1KMT2ACNR1 | |
| SCHEMBL7103531 | 0.74 | MEN1 (0.33) | MEN1KMT2APNP | |
| SCHEMBL7103540 | 0.73 | MEN1 (0.34) | MEN1KMT2ACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |