Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.31 |
| ▸ | PNP | P00491 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655696 | 0.83 | P4HTM (0.40) | KMT2AROCK2ROCK1PNPALDH1A1 | |
| SCHEMBL7108649 | 0.81 | TSPO (0.30) | MEN1KMT2AROCK2ROCK1ALDH1A1 | |
| SCHEMBL7103591 | 0.80 | SIRT6 (0.31) | SIRT6 | |
| SCHEMBL7104707 | 0.79 | PNP (0.36) | MEN1KMT2APNP | |
| SCHEMBL7661222 | 0.78 | TDP1 (0.41) | ALDH1A1POLBKDM4E | |
| SCHEMBL7663615 | 0.78 | SIRT6 (0.30) | SIRT6 | |
| SCHEMBL7654697 | 0.77 | MEN1 (0.31) | MEN1KMT2A | |
| SCHEMBL7106680 | 0.74 | MEN1 (0.36) | MEN1KMT2APNP | |
| SCHEMBL7651968 | 0.74 | KDM4E (0.40) | MEN1KMT2AROCK2ROCK1ALDH1A1 | |
| SCHEMBL7106490 | 0.73 | MEN1 (0.36) | MEN1KMT2AROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |