Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18130956 | 0.90 | SIRT6 (0.47) | SMOMEN1KMT2APOLBHDAC4 | |
| SCHEMBL7655050 | 0.83 | HDAC4 (0.44) | HDAC4CYP11B2PDK2TLR9TLR8 | |
| SCHEMBL24341942 | 0.83 | TDP1 (0.42) | SMOHDAC4HTR2CCNR1MAPT | |
| SCHEMBL20327068 | 0.81 | MTOR (0.39) | SMOHDAC4HTR2CLRRK2PDK2 | |
| SCHEMBL7107359 | 0.81 | HDAC4 (0.39) | SMOKMT2APOLBHDAC4HTR2C | |
| SCHEMBL18348214 | 0.80 | MAPT (0.36) | SMOMEN1KMT2AHDAC4HTR2C | |
| SCHEMBL7105124 | 0.79 | L3MBTL1 (0.41) | POLBCNR1MAPT | |
| SCHEMBL25094798 | 0.79 | ESRRG (0.41) | MEN1KMT2AHDAC4 | |
| SCHEMBL24800710 | 0.79 | HDAC4 (0.34) | SMOMEN1KMT2AHDAC4CYP11B2 | |
| SCHEMBL7652649 | 0.77 | HTR2C (0.46) | MEN1KMT2AHDAC4HTR2CCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |