Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 13/20 | 0.68 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.68 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.68 |
| ▸ | AURKA | O14965 | 2/20 | 0.61 |
| ▸ | JAK2 | O60674 | 2/20 | 0.61 |
| ▸ | JAK3 | P52333 | 2/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | JAK1 | P23458 | 1/20 | 0.61 |
| ▸ | TYK2 | P29597 | 1/20 | 0.61 |
| ▸ | TTK | P33981 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.61 |
| ▸ | SYK | P43405 | 2/20 | 0.57 |
| ▸ | TOP2A | P11388 | 1/20 | 0.57 |
| ▸ | BTK | Q06187 | 2/20 | 0.57 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7104518 | 0.84 | ADORA3 (0.93) | ADORA3ADORA1ADORA2AAURKAJAK2 | |
| SCHEMBL7106970 | 0.84 | SYK (0.50) | ADORA3ADORA1ADORA2AAURKAJAK2 | |
| SCHEMBL31747057 | 0.79 | ADORA3 (0.74) | ADORA3ADORA1ADORA2AAURKAJAK2 | |
| Hydrochloric Acid SCHEMBL29369317 | 0.78 | ADORA3 (0.72) | ADORA3ADORA1ADORA2AAURKAJAK2 | |
| Reversine SCHEMBL1800795 | 0.76 | ADORA3 (1.00) | ADORA3ADORA1ADORA2AAURKAJAK2 | |
| Puquitinib SCHEMBL29366562 | 0.73 | PIK3CD (0.98) | ADORA3ADORA1ADORA2AAURKAJAK2 | |
| SCHEMBL7105981 | 0.72 | XDH (0.59) | ADORA3ADORA1ADORA2ABTK | |
| Puquitinib SCHEMBL29412443 | 0.72 | PIK3CD (1.00) | ADORA3ADORA1ADORA2AAURKAJAK2 | |
| Puquitinib SCHEMBL30157235 | 0.72 | PIK3CD (1.00) | ADORA3ADORA1ADORA2AAURKAJAK2 | |
| SCHEMBL7626878 | 0.70 | LMNA (0.58) | ADORA3ADORA1ADORA2ABTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1213047-C | Puring derivatives inhibitors of tyrosine kinase SYK | NOVARTIS AG (CH) | 2005-08-03 | — | — | CN | disclosed |
| EP-1200435-B1 | PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK | NOVARTIS AG (CH) | 2003-10-01 | — | — | EP | disclosed |
| US-6589950-B1 | Treatment of inflammatory or obstructive airways disease for respiratory system disorders | NOVARTIS AG (CH) | 2003-07-08 | — | — | US | disclosed |
| CN-1365360-A | purine derivative inhibitors of tyrosine protein kinase SYK | NOVARTIS AG (CH) | 2002-08-21 | — | — | CN | disclosed |
| EP-1200435-A1 | PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK | Novartis AG (CH) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001009134-A1 | PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK | NOVARTIS AG (CH) | 2001-02-08 | — | — | WO | disclosed |