Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 3/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7105914 | 0.91 | ALDH1A1 (0.47) | TSHRALDH1A1MAPTPOLBHPGD | |
| SCHEMBL7111821 | 0.89 | PPARG (0.46) | TSHRALDH1A1MAPTPOLBHPGD | |
| SCHEMBL7111084 | 0.89 | PPARG (0.46) | TSHRALDH1A1MAPTPOLBHPGD | |
| SCHEMBL7196291 | 0.83 | TSHR (0.45) | TSHRALDH1A1MAPTPOLBHPGD | |
| SCHEMBL5100515 | 0.82 | MAPT (0.53) | ALDH1A1MAPTPOLBPPARGPPARA | |
| SCHEMBL5100738 | 0.82 | MAPT (0.45) | TSHRALDH1A1MAPTHPGDPPARG | |
| SCHEMBL8304776 | 0.80 | NPC1 (0.45) | POLBPPARGPPARAMEN1KMT2A | |
| SCHEMBL11787640 | 0.79 | ALDH1A1 (0.58) | TSHRALDH1A1MAPTPOLBHPGD | |
| SCHEMBL7035857 | 0.78 | PPARG (0.75) | PPARGPPARA | |
| SCHEMBL6531313 | 0.78 | MAPT (0.48) | TSHRALDH1A1MAPTPOLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003006022-A1 | TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DR. REDDY'S LABORATORIES LTD. (IN) | 2003-01-23 | — | — | WO | claimed |
| WO-2003006022-A1 | TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DR. REDDY'S LABORATORIES LTD. (IN) | 2003-01-23 | — | — | WO | disclosed |