Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8164140 | 0.87 | KMT2A (0.44) | ALDH1A1MEN1KMT2ALMNANPSR1 | |
| SCHEMBL7454203 | 0.86 | HTR2A (0.50) | HTR2ASLC6A4TBXA2RKCNH2SLC6A2 | |
| SCHEMBL8169868 | 0.85 | TBXA2R (0.45) | SLC6A4TBXA2RSLC6A2SLC6A3ALDH1A1 | |
| SCHEMBL2881204 | 0.83 | SLC6A4 (0.55) | HTR2ASLC6A4KCNH2SLC6A2SLC6A3 | |
| SCHEMBL7112299 | 0.83 | SLC6A4 (0.65) | HTR2ASLC6A4KCNH2SLC6A2SLC6A3 | |
| SCHEMBL5836477 | 0.83 | SLC6A4 (0.66) | HTR2ASLC6A4TBXA2RKCNH2SLC6A2 | |
| SCHEMBL4019396 | 0.82 | HTR2A (0.56) | HTR2ASLC6A4KCNH2SLC6A2SLC6A3 | |
| SCHEMBL3946409 | 0.82 | HTR2A (0.56) | HTR2ASLC6A4KCNH2SLC6A2SLC6A3 | |
| SCHEMBL6682249 | 0.82 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2AGAALMNA | |
| SCHEMBL3944807 | 0.82 | SLC6A4 (0.48) | HTR2ASLC6A4KCNH2SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596741-B2 | Compounds of formula I exhibit activity as serotonin, norepinephrine, and dopamine reuptake inhibitors and can be used in the treatment of central nervous system and other disorders. | PFIZER INC | 2003-07-22 | — | — | US | disclosed |
| US-20030055038-A1 | Novel biaryl ether derivatives useful as monoamine reuptake inhibitors | PFIZER INC. | 2003-03-20 | — | — | US | disclosed |
| US-6410736-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | PFIZER INC. | 2002-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030055038-A1 | Novel biaryl ether derivatives useful as monoamine reuptake inhibitors | SLC6A2, SLC6A3, SLC18A2 | HTR2A 24/4885SLC6A4 6/4885TBXA2R 437/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.