Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | WDR5 | P61964 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PRKCG | P05129 | 4/20 | 0.40 |
| ▸ | PRKCB | P05771 | 4/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.40 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.40 |
| ▸ | PRKCA | P17252 | 2/20 | 0.40 |
| ▸ | PRKACA | P17612 | 2/20 | 0.40 |
| ▸ | PRKACG | P22612 | 2/20 | 0.40 |
| ▸ | PRKACB | P22694 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7107511 | 1.00 | KDM4E (0.45) | KDM4EGAAWDR5NPC1RAB9A | |
| SCHEMBL7149111 | 0.91 | GAA (0.43) | KDM4EGAAWDR5NPC1RAB9A | |
| SCHEMBL7149107 | 0.85 | ALDH1A1 (0.41) | KMT2AMAPTMEN1ALDH1A1POLB | |
| SCHEMBL7149109 | 0.85 | ALDH1A1 (0.41) | KMT2AMAPTMEN1ALDH1A1POLB | |
| SCHEMBL7101763 | 0.83 | KDM4E (0.48) | KDM4EGAAMAPTALDH1A1PRKCG | |
| SCHEMBL7105112 | 0.82 | NPC1 (0.46) | GAAWDR5NPC1RAB9AKMT2A | |
| SCHEMBL7105107 | 0.82 | NPC1 (0.46) | GAAWDR5NPC1RAB9AKMT2A | |
| SCHEMBL7107509 | 0.82 | KDM4E (0.47) | KDM4EPRKCGPRKCBPRKCDPRKCE | |
| SCHEMBL4867624 | 0.77 | CHRM1 (0.50) | GAAWDR5NPC1RAB9AKMT2A | |
| SCHEMBL4867618 | 0.77 | CHRM1 (0.50) | GAAWDR5NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923543-B1 | POTASSIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2003-09-24 | — | — | EP | disclosed |
| US-6083986-A | Potassium channel inhibitors | ICAGEN, INC. (US) | 2000-07-04 | — | — | US | disclosed |