Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 8/20 | 0.43 |
| ▸ | WDR5 | P61964 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7107514 | 0.91 | KDM4E (0.45) | GAAWDR5KDM4EEPHX1KMT2A | |
| SCHEMBL7107511 | 0.91 | KDM4E (0.45) | GAAWDR5KDM4EEPHX1KMT2A | |
| SCHEMBL7149107 | 0.86 | ALDH1A1 (0.41) | KMT2AMAPTMEN1ALDH1A1TP53 | |
| SCHEMBL7149109 | 0.86 | ALDH1A1 (0.41) | KMT2AMAPTMEN1ALDH1A1TP53 | |
| SCHEMBL7101251 | 0.76 | CYP3A4 (0.43) | KDM4EMAPTALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL7101254 | 0.76 | CYP3A4 (0.43) | KDM4EMAPTALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL7105112 | 0.75 | NPC1 (0.46) | GAAWDR5KMT2AMAPTMEN1 | |
| SCHEMBL7105107 | 0.75 | NPC1 (0.46) | GAAWDR5KMT2AMAPTMEN1 | |
| SCHEMBL7101763 | 0.73 | KDM4E (0.48) | GAAKDM4EMAPTALDH1A1HTT | |
| SCHEMBL4867618 | 0.69 | CHRM1 (0.50) | GAAWDR5KMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923543-B1 | POTASSIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2003-09-24 | — | — | EP | disclosed |
| US-6083986-A | Potassium channel inhibitors | ICAGEN, INC. (US) | 2000-07-04 | — | — | US | disclosed |