Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 7/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | IGF2BP2 | Q9Y6M1 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 2/20 | 0.35 |
| ▸ | BRAF | P15056 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.35 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | ARAF | P10398 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7112858 | 0.81 | CCR2 (0.44) | CCR2KDM4EALDH1A1HPGDCFTR | |
| SCHEMBL12847269 | 0.76 | HSD17B2 (0.46) | KDM4EGAAKMT2AIGF2BP2ALDH1A1 | |
| SCHEMBL1438883 | 0.75 | KDM4E (0.55) | KDM4EGAAKMT2AALDH1A1HPGD | |
| SCHEMBL13754026 | 0.75 | HDAC1 (0.53) | CCR2KDM4EGAAKMT2AIGF2BP2 | |
| SCHEMBL13043978 | 0.73 | PIM1 (0.43) | CCR2KDM4EGAAKMT2AIGF2BP2 | |
| SCHEMBL30951611 | 0.73 | PIM1 (0.43) | CCR2KDM4EGAAKMT2AIGF2BP2 | |
| SCHEMBL15635765 | 0.73 | CCR2 (0.39) | PDE2ACCR2KDM4EGAAKMT2A | |
| SCHEMBL5439114 | 0.73 | CCR2 (0.51) | CCR2KDM4EGAAKMT2AALDH1A1 | |
| SCHEMBL4091950 | 0.72 | CHEK1 (0.47) | CCR2KDM4EGAAKMT2AIGF2BP2 | |
| SCHEMBL1046271 | 0.72 | KEAP1 (0.53) | KDM4EKMT2AIGF2BP2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351924-A2 | DIAMINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Bristol-Myers Squibb Pharma Company (US) | 2003-10-15 | — | — | EP | claimed |
| WO-2002050019-A2 | DIAMINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB PHARMA CO. (US) | 2002-06-27 | — | — | WO | claimed |