Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 11/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.39 |
| ▸ | FEN1 | P39748 | 4/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7107925 | 0.81 | PDE2A (0.39) | CCR2CFTRKDM4EALDH1A1HPGD | |
| SCHEMBL13754412 | 0.81 | CFTR (0.48) | CCR2CFTRKDM4EALDH1A1HPGD | |
| SCHEMBL13754410 | 0.81 | NPSR1 (0.56) | CCR2CFTRKDM4EALDH1A1HPGD | |
| SCHEMBL7109974 | 0.78 | RXFP1 (0.51) | CCR2 | |
| SCHEMBL7154000 | 0.77 | L3MBTL1 (0.42) | CCR2ALDH1A1 | |
| SCHEMBL13754426 | 0.76 | ALOX5AP (0.57) | CCR2CFTRKDM4EALDH1A1HPGD | |
| SCHEMBL30223377 | 0.76 | CFTR (0.54) | CCR2CFTRKDM4EALDH1A1HPGD | |
| SCHEMBL2184572 | 0.76 | CFTR (0.54) | CCR2CFTRKDM4EALDH1A1HPGD | |
| SCHEMBL7107910 | 0.75 | NPSR1 (0.41) | CCR2PTGS1 | |
| SCHEMBL7109818 | 0.75 | RXFP1 (0.51) | CCR2KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351924-A2 | DIAMINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Bristol-Myers Squibb Pharma Company (US) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002050019-A2 | DIAMINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB PHARMA CO. (US) | 2002-06-27 | — | — | WO | disclosed |