Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.41 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 4/20 | 0.40 |
| ▸ | ACHE | P22303 | 4/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | USP1 | O94782 | 2/20 | 0.36 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24341942 | 0.84 | TDP1 (0.42) | HDAC4KDM4E | |
| SCHEMBL7108522 | 0.83 | SMO (0.40) | HDAC4PDK2CYP11B2TLR9TLR8 | |
| SCHEMBL20327068 | 0.83 | MTOR (0.39) | HDAC4PDK2 | |
| SCHEMBL10795881 | 0.80 | HDAC4 (0.54) | HDAC4PDK2CYP11B2TLR9TLR8 | |
| SCHEMBL7655871 | 0.80 | P4HTM (0.38) | P4HTMP4HA1MIFBCHEACHE | |
| SCHEMBL25094798 | 0.80 | ESRRG (0.41) | HDAC4 | |
| SCHEMBL24800710 | 0.80 | HDAC4 (0.34) | HDAC4CYP11B2 | |
| SCHEMBL7656690 | 0.80 | P4HTM (0.43) | P4HTMP4HA1MIFMAPK1HCAR3 | |
| SCHEMBL7658471 | 0.79 | ROCK2 (0.39) | P4HTMP4HA1MIFBCHEACHE | |
| SCHEMBL7658827 | 0.78 | P4HTM (0.36) | P4HTMP4HA1MIFBCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |