Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 7/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | CDK2 | P24941 | 11/20 | 0.54 |
| ▸ | CDK1 | P06493 | 6/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.53 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.53 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.53 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.49 |
| ▸ | CDK7 | P50613 | 2/20 | 0.49 |
| ▸ | CDK9 | P50750 | 2/20 | 0.49 |
| ▸ | CCNH | P51946 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10798703 | 0.84 | POLA1 (1.00) | POLA1MEN1NPC1MAPTHPGD | |
| SCHEMBL7108860 | 0.83 | POLA1 (0.71) | POLA1MEN1NPC1MAPTHPGD | |
| SCHEMBL7107635 | 0.82 | POLA1 (1.00) | POLA1MEN1NPC1MAPTHPGD | |
| SCHEMBL3496871 | 0.74 | POLA1 (1.00) | POLA1 | |
| SCHEMBL10798696 | 0.71 | POLA1 (0.69) | POLA1MEN1NPC1MAPTHPGD | |
| SCHEMBL3305088 | 0.71 | PIN1 (0.73) | POLA1CDK2CDK1CCNB1CCNA2 | |
| SCHEMBL1264648 | 0.70 | STK17A (0.54) | POLA1 | |
| SCHEMBL1266331 | 0.70 | STK17A (0.54) | POLA1 | |
| SCHEMBL7107628 | 0.69 | POLA1 (0.71) | POLA1MEN1NPC1MAPTHPGD | |
| SCHEMBL6785454 | 0.69 | CCNA2 (1.00) | CDK2CDK1CCNB1CCNA2CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200435-B1 | PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK | NOVARTIS AG (CH) | 2003-10-01 | — | — | EP | claimed |
| US-6589950-B1 | Treatment of inflammatory or obstructive airways disease for respiratory system disorders | NOVARTIS AG (CH) | 2003-07-08 | — | — | US | claimed |
| JP-2003506375-A | — | — | 2003-02-18 | — | — | JP | claimed |
| EP-1200435-A1 | PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK | Novartis AG (CH) | 2002-05-02 | — | — | EP | claimed |
| WO-2001009134-A1 | PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK | NOVARTIS AG (CH) | 2001-02-08 | — | — | WO | claimed |
| EP-1200435-B1 | PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK | NOVARTIS AG (CH) | 2003-10-01 | — | — | EP | disclosed |
| US-6589950-B1 | Treatment of inflammatory or obstructive airways disease for respiratory system disorders | NOVARTIS AG (CH) | 2003-07-08 | — | — | US | disclosed |
| EP-1200435-A1 | PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK | Novartis AG (CH) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001009134-A1 | PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK | NOVARTIS AG (CH) | 2001-02-08 | — | — | WO | disclosed |