Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PNP | P00491 | 1/20 | 0.31 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | AGER | Q15109 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7107785 | 0.85 | MTAP (0.32) | TYMP | |
| SCHEMBL7106657 | 0.84 | PNP (0.39) | PNP | |
| SCHEMBL7655922 | 0.83 | TYMP (0.39) | TYMPS1PR1MEN1POLBKMT2A | |
| SCHEMBL7108600 | 0.82 | TYMP (0.41) | TYMPS1PR1MEN1POLBKMT2A | |
| SCHEMBL7104647 | 0.82 | PNP (0.32) | PNP | |
| SCHEMBL7656330 | 0.79 | ALDH1A1 (0.40) | TYMPS1PR1MEN1POLBKMT2A | |
| SCHEMBL7658936 | 0.74 | KMT2A (0.45) | TYMPS1PR1MEN1POLBKMT2A | |
| SCHEMBL7109239 | 0.74 | HSD17B10 (0.41) | POLBKDM4EL3MBTL1PNP | |
| SCHEMBL10424283 | 0.74 | LMNA (0.47) | TYMPKDM4EL3MBTL1DNM1ALDH1A1 | |
| SCHEMBL7108544 | 0.73 | PNP (0.36) | PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |