⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8205927 | 0.75 | CYP2A6 (0.39) | — | |
| SCHEMBL16720573 | 0.74 | METAP2 (0.36) | — | |
| SCHEMBL7453541 | 0.73 | METAP2 (0.32) | — | |
| SCHEMBL7446763 | 0.72 | NPC1 (0.39) | — | |
| SCHEMBL28872405 | 0.72 | APP (0.50) | — | |
| SCHEMBL10535184 | 0.72 | APP (0.46) | — | |
| SCHEMBL19127576 | 0.71 | ERN1 (0.40) | — | |
| SCHEMBL7447711 | 0.71 | ALDH1A1 (0.38) | — | |
| SCHEMBL7110942 | 0.71 | PDPK1 (0.40) | — | |
| SCHEMBL7453756 | 0.70 | CLK4 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030008901-A1 | Hydroxy pipecolate hydroxamic acid derivatives | MCCLURE KIM F (US) | 2003-01-09 | — | — | US | disclosed |
| US-20020019534-A1 | Gem substituted hydroxamic acids | PFIZER INC. | 2002-02-14 | — | — | US | disclosed |
| CN-1316995-A | Hydroxy 2-piperidinoate hydroxamic acid derivatives as MMP inhibitors | PFIZER PROD INC (US) | 2001-10-10 | — | — | CN | disclosed |