Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7108782 | 0.84 | SRD5A2 (0.30) | ALDH1A1NPC1RAB9ASRD5A2 | |
| Hydrochloric Acid SCHEMBL719838 | 0.77 | NPC1 (0.40) | ALDH1A1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL715011 | 0.76 | METAP1 (0.30) | — | |
| Hydrochloric Acid SCHEMBL715869 | 0.74 | TDP2 (0.34) | — | |
| SCHEMBL8390466 | 0.74 | NPC1 (0.39) | ALDH1A1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL7104812 | 0.71 | — | — | |
| Hydrochloric Acid SCHEMBL7918192 | 0.71 | NPC1 (0.37) | ALDH1A1NPC1RAB9ASRD5A2 | |
| Hydrochloric Acid SCHEMBL713175 | 0.71 | TYRO3 (0.32) | — | |
| Hydrochloric Acid SCHEMBL713828 | 0.71 | PDE5A (0.31) | — | |
| Hydrochloric Acid SCHEMBL715303 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0908435-B1 | Method for purifying transition metal compounds | SUMITOMO CHEMICAL CO (JP) | 2003-10-01 | — | — | EP | disclosed |
| US-6107502-A | Method for purifying transition metal compound and method for producing the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2000-08-22 | — | — | US | disclosed |
| EP-0908435-A1 | Method for purifying transition metal compound and method for producing the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1999-04-14 | — | — | EP | disclosed |