Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 5/20 | 0.35 |
| ▸ | AURKA | O14965 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7113350 | 0.89 | RXRA (0.40) | KITMGLLCYP17A1AURKA | |
| SCHEMBL7111871 | 0.83 | ERCC5 (0.47) | CYP17A1AURKACYP3A4 | |
| SCHEMBL7117074 | 0.82 | ABL1 (0.39) | SCN5ASCN9AS1PR1 | |
| SCHEMBL7115204 | 0.80 | KMO (0.36) | CSF1RKITSCN5ASCN9A | |
| SCHEMBL7113378 | 0.80 | ABL1 (0.38) | CSF1RKITSCN5ASCN9A | |
| SCHEMBL7047983 | 0.79 | AAK1 (0.33) | SCN5ASCN9ACYP3A4AAK1 | |
| SCHEMBL17336851 | 0.79 | POLB (0.35) | — | |
| SCHEMBL7042573 | 0.78 | RXRA (0.36) | AAK1 | |
| SCHEMBL17336825 | 0.78 | RXFP1 (0.35) | — | |
| SCHEMBL7112784 | 0.78 | SCN5A (0.35) | CSF1RKITSCN5ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474416-A1 | DIHYDROBENZODIAZEPIN-2-ONE-DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-10 | — | — | EP | disclosed |
| WO-2003066623-A1 | DIHYDROBENZODIAZEPIN-2-ONE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-08-14 | — | — | WO | disclosed |