Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 5/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.33 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.33 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7115204 | 0.86 | KMO (0.36) | SCN5ASCN9AKMOCYP1A2HTR2A | |
| SCHEMBL7114425 | 0.82 | PLOD2 (0.42) | SCN5ASCN9AKMT2ACYP1A2HTR2A | |
| SCHEMBL7151045 | 0.81 | CNR1 (0.41) | TSHRKMOKMT2A | |
| SCHEMBL7044470 | 0.80 | GRM2 (0.35) | SYK | |
| SCHEMBL7113378 | 0.80 | ABL1 (0.38) | SCN5ASCN9ACSF1RKIT | |
| SCHEMBL5557540 | 0.79 | SCN5A (0.41) | SCN5ASCN9ATSHRMAPK1KMO | |
| SCHEMBL5562067 | 0.78 | AAK1 (0.36) | SCN9A | |
| SCHEMBL7117074 | 0.78 | ABL1 (0.39) | SCN5ASCN9A | |
| SCHEMBL7109630 | 0.78 | CSF1R (0.38) | SCN5ASCN9ACSF1RKIT | |
| SCHEMBL7047983 | 0.77 | AAK1 (0.33) | SCN5ASCN9AKMOSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474416-A1 | DIHYDROBENZODIAZEPIN-2-ONE-DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-10 | — | — | EP | disclosed |
| WO-2003066623-A1 | DIHYDROBENZODIAZEPIN-2-ONE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-08-14 | — | — | WO | disclosed |