Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7035683 | 0.94 | GPR3 (0.31) | HTR2ACYP2D6 | |
| Hydrochloric Acid SCHEMBL2538854 | 0.86 | HTR2A (0.36) | HTR6HTR2ACYP2D6 | |
| SCHEMBL7035253 | 0.79 | HTR2A (0.34) | HTR6HTR2ACYP2D6 | |
| Hydrochloric Acid SCHEMBL6902433 | 0.78 | CYP19A1 (0.39) | HTR2ACYP2D6 | |
| Hydrochloric Acid SCHEMBL713786 | 0.76 | POLB (0.33) | CYP2D6 | |
| Hydrochloric Acid SCHEMBL396459 | 0.76 | HTR2A (0.33) | HTR2ACYP2D6 | |
| Hydrochloric Acid SCHEMBL6903918 | 0.74 | ATM (0.30) | CYP2D6 | |
| Hydrochloric Acid SCHEMBL30630878 | 0.74 | HTR2A (0.39) | HTR6HTR2ACYP2D6 | |
| SCHEMBL7027384 | 0.73 | HTR2A (0.33) | HTR6HTR2ACYP2D6 | |
| SCHEMBL7032620 | 0.72 | KDM4E (0.32) | HTR2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0908435-B1 | Method for purifying transition metal compounds | SUMITOMO CHEMICAL CO (JP) | 2003-10-01 | — | — | EP | disclosed |
| US-6107502-A | Method for purifying transition metal compound and method for producing the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2000-08-22 | — | — | US | disclosed |
| EP-0908435-A1 | Method for purifying transition metal compound and method for producing the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1999-04-14 | — | — | EP | disclosed |