SCHEMBL711050

SCHEMBL711050

CCC(O)/C=C(\C)C(=O)O

nearest known ligand 0.38

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
GAPDH P04406 1/20 0.38
PTPN11 Q06124 1/20 0.33
CMKLR1 Q99788 1/20 0.32
PTGS1 P23219 1/20 0.31
AKR1C3 P42330 1/20 0.31
FFAR3 O14843 1/20 0.31
HDAC3 O15379 1/20 0.31
HDAC1 Q13547 1/20 0.31
HDAC2 Q92769 1/20 0.31
HDAC8 Q9BY41 1/20 0.31
APEX1 P27695 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16667 1.00 GAPDH (0.38) GAPDHPTPN11CMKLR1PTGS1AKR1C3
Phosphoric Acid SCHEMBL21408816 0.92 GRIN2D (0.34) GAPDHPTPN11
SCHEMBL8426286 0.92 GAPDH (0.33) GAPDHPTPN11
SCHEMBL10753894 0.90 GAPDH (0.32) GAPDHPTPN11
SCHEMBL9781496 0.90 GRIK1 (0.34) GAPDHPTPN11
SCHEMBL7713662 0.90 HDAC1 (0.35) GAPDHPTPN11CMKLR1FFAR3HDAC3
SCHEMBL23036469 0.85
Malic Acid SCHEMBL14740589 0.85 SMN1; SMN2 (0.52)
SCHEMBL1784421 0.83 GAPDH (0.39) GAPDH
SCHEMBL1784419 0.83 GAPDH (0.39) GAPDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 161 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180318473-A1 DRUGS WITH IMPROVED HYDROPHOBICITY FOR INCORPORATION IN MEDICAL DEVICES ABRAXIS BIOSCIENCE LLC (US) 2018-11-08 US claimed
EP-3345632-A1 DRUGS WITH IMPROVED HYDROPHOBICITY FOR INCORPORATION IN MEDICAL DEVICES Abraxis BioScience, LLC (US) 2018-07-11 EP claimed
EP-3345631-A1 DRUGS WITH IMPROVED HYDROPHOBICITY FOR INCORPORATION IN MEDICAL DEVICES Abraxis BioScience, LLC (US) 2018-07-11 EP claimed
US-9954126-B2 Three-dimensional photovoltaic devices including cavity-containing cores and methods of manufacture Q1 NANOSYSTEMS CORPORATION (US) 2018-04-24 US claimed
EP-1861070-B1 DRUGS WITH IMPROVED HYDROPHOBICITY FOR INCORPORATION IN MEDICAL DEVICES ABRAXIS BIOSCIENCE LLC (US) 2018-01-17 EP claimed
US-20170203012-A1 DRUGS WITH IMPROVED HYDROPHOBICITY FOR INCORPORATION IN MEDICAL DEVICES ABRAXIS BIOSCIENCE LLC (US) 2017-07-20 US claimed
US-20160043251-A1 Three-Dimensional Photovoltaic Devices Including Cavity-containing Cores and Methods of Manufacture ACADIA WOODS PARTNERS, LLC 2016-02-11 US claimed
US-20160043253-A1 Methods for Manufacturing Three-Dimensional Metamaterial Devices with Photovoltaic Bristles ACADIA WOODS PARTNERS, LLC 2016-02-11 US claimed
EP-2896412-A1 Drugs with improved hydrophobicity for incorporation in medical devices Abraxis BioScience, LLC (US) 2015-07-22 EP claimed
US-20150190556-A1 DRUGS WITH IMPROVED HYDROPHOBICITY FOR INCORPORATION IN MEDICAL DEVICES ABRAXIS BIOSCIENCE LLC (US) 2015-07-09 US claimed
WO-2006020742-A2 MEDICAL DEVICES HAVING NANOPOROUS LAYERS AND METHODS FOR MAKING THE SAME SETAGON, INC. (US) 2006-02-23 WO claimed
US-20050137684-A1 Stent with therapeutically active drug coated thereon PFIZER INC 2005-06-23 US claimed
US-20050085902-A1 Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures,Including delivery using a modified stent CARDINAL HEALTH SWITZERLAND 515 GmbH (CH) 2005-04-21 US claimed
EP-1407726-A1 Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent Cordis Corporation (US) 2004-04-14 EP claimed
US-6585764-B2 Stent with therapeutically active dosage of rapamycin coated thereon CORDIS CORPORATION 2003-07-01 US claimed
EP-0587565-B1 INTRAOCULAR LENS WITH HAPTIC ANCHOR PLATE MEDEVEC LICENSING BV (NL) 1998-08-19 EP claimed
EP-0587565-A4 INTRAOCULAR LENS WITH HAPTIC ANCHOR PLATE. CUMMING STUART J (US) 1995-02-22 EP claimed
EP-0587565-A1 INTRAOCULAR LENS WITH HAPTIC ANCHOR PLATE MEDEVEC LICENSING B.V. (NL) 1994-03-23 EP claimed
WO-1992021304-A1 INTRAOCULAR LENS WITH HAPTIC ANCHOR PLATE CUMMING STUART J (US) 1992-12-10 WO claimed
US-5047051-A Intraocular lens with haptic anchor plate THE NICE TRUST, A TRUST OF THE ISLE OF MAN 1991-09-10 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170203012-A1 DRUGS WITH IMPROVED HYDROPHOBICITY FOR INCORPORATION IN MEDICAL DEVICES MIF, MKI67, ABCB11 GAPDH 3259/4885PTPN11 3307/4885CMKLR1 876/4885
US-20180318473-A1 DRUGS WITH IMPROVED HYDROPHOBICITY FOR INCORPORATION IN MEDICAL DEVICES MIF, MKI67, ABCB11 GAPDH 3259/4885PTPN11 3307/4885CMKLR1 876/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.