Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7107993 | 0.94 | SMN1; SMN2 (0.46) | HPGDALDH1A1RECQLATG4BSMN1; SMN2 | |
| SCHEMBL30145626 | 0.90 | SMN1; SMN2 (0.47) | HPGDALDH1A1RECQLSMN1; SMN2MEN1 | |
| SCHEMBL7105040 | 0.90 | HPGD (0.54) | HPGDALDH1A1RECQLSMN1; SMN2MEN1 | |
| SCHEMBL28945656 | 0.84 | SIRT6 (0.46) | HPGDALDH1A1RECQLSMN1; SMN2KMT2A | |
| SCHEMBL27730675 | 0.83 | SIRT6 (0.51) | HPGDALDH1A1RECQLMEN1KMT2A | |
| SCHEMBL17008547 | 0.81 | NPC1 (0.47) | HPGDALDH1A1RECQLRAB9ANPC1 | |
| SCHEMBL31086788 | 0.81 | NPC1 (0.47) | HPGDALDH1A1RECQLRAB9ANPC1 | |
| SCHEMBL28578424 | 0.76 | KDM4E (0.64) | HPGDSMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL31086597 | 0.76 | KDM4E (0.64) | HPGDSMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL7109278 | 0.76 | LMNA (0.41) | HPGDALDH1A1SMN1; SMN2RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |