Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.63 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.63 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 3/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.61 |
| ▸ | ELANE | P08246 | 1/20 | 0.60 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15670648 | 0.87 | RXFP1 (0.57) | TSHRCYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL7318284 | 0.87 | RXFP1 (0.57) | TSHRCYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL1801492 | 0.87 | TSHR (0.59) | TSHRCYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL8623142 | 0.84 | DHODH (0.68) | RXFP1KMT2AMEN1SMN1; SMN2MMP1 | |
| SCHEMBL11665959 | 0.84 | TSHR (0.77) | TSHRCYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL8417469 | 0.83 | MMP1 (0.65) | POLBRXFP1ALDH1A1MAPTKMT2A | |
| SCHEMBL28857391 | 0.83 | RXFP1 (0.55) | TSHRCYP1A2CYP2D6CYP2C19POLB | |
| SCHEMBL9339256 | 0.82 | TSHR (0.76) | TSHRCYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL4203434 | 0.82 | TSHR (0.76) | TSHRCYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL8714750 | 0.82 | MLYCD (0.63) | APOBEC3AAPOBEC3GPOLBRXFP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1439834-A1 | OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | Applied Research Systems ARS Holding N.V. (AN) | 2004-07-28 | — | — | EP | disclosed |
| WO-2003037328-A1 | OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2003-05-08 | — | — | WO | disclosed |