Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 11/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7110569 | 0.92 | PTGS2 (0.60) | PTGS2ESR1ESR2FFAR4PTGS1 | |
| SCHEMBL6722957 | 0.88 | PTGS2 (0.50) | PTGS2ESR1ESR2FFAR4PTGS1 | |
| SCHEMBL6721315 | 0.88 | PTGS2 (0.59) | PTGS2ESR1ESR2FFAR4PTGS1 | |
| SCHEMBL7112086 | 0.87 | PTGS2 (0.47) | PTGS2ESR1ESR2FFAR4PTGS1 | |
| SCHEMBL6728996 | 0.82 | PTGS2 (0.46) | PTGS2ESR1ESR2FFAR4PTGS1 | |
| SCHEMBL6722930 | 0.82 | PTGS2 (0.54) | PTGS2ESR1ESR2FFAR4PTGS1 | |
| SCHEMBL7110955 | 0.81 | MAPK14 (0.36) | PTGS2FFAR4PTGS1RAB9ACA1 | |
| SCHEMBL7110302 | 0.81 | PTGS2 (0.47) | PTGS2FFAR4PTGS1 | |
| SCHEMBL6722713 | 0.80 | PTGS2 (0.60) | PTGS2ESR1ESR2FFAR4PTGS1 | |
| SCHEMBL6723456 | 0.80 | PTGS2 (0.70) | PTGS2ESR1ESR2FFAR4PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296971-A2 | 2-FLUOROBENZENESULFONYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001081332-A2 | 2-FLUOROBENZENESULFONYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2001-11-01 | — | — | WO | disclosed |