Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzenesulfonamide SCHEMBL7927040 | 0.94 | PTGS2 (0.60) | PTGS2PTGS1ALDH1A1CYP2C9LMNA | |
| SCHEMBL8688860 | 0.91 | PTGS2 (0.52) | PTGS2PTGS1 | |
| SCHEMBL8635921 | 0.89 | PTGS2 (0.46) | PTGS2PTGS1 | |
| SCHEMBL8688703 | 0.88 | PTGS2 (0.41) | PTGS2PTGS1ALDH1A1 | |
| SCHEMBL8618309 | 0.88 | PTGS2 (0.51) | PTGS2PTGS1 | |
| Benzene SCHEMBL7058431 | 0.88 | PTGS2 (0.51) | PTGS2PTGS1 | |
| SCHEMBL8688398 | 0.87 | PTGS1 (0.53) | PTGS2PTGS1MAPTNPY5RALDH1A1 | |
| SCHEMBL8636817 | 0.87 | PTGS2 (0.42) | PTGS2PTGS1ALDH1A1 | |
| SCHEMBL8639178 | 0.86 | PTGS2 (0.43) | PTGS2PTGS1NPY5RALDH1A1CYP2C9 | |
| SCHEMBL8689218 | 0.85 | PTGS2 (0.41) | PTGS2PTGS1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299122-A2 | COMBINATION OF A COX-2 INHIBITOR AND A VASOMODULATOR FOR TREATING PAIN AND HEADACHE PAIN | Pharmacia Corporation (US) | 2003-04-09 | — | — | EP | claimed |
| WO-2002005799-A2 | COMBINATION OF A COX-2 INHIBITOR AND A VASOMODULATOR FOR TREATING PAIN AND HEADACHE PAIN | PHARMACIA CORPORATION (US) | 2002-01-24 | — | — | WO | claimed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | claimed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |