Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8688860 | 0.88 | PTGS2 (0.52) | PTGS2PTGS1MMP2MMP1MMP13 | |
| SCHEMBL7112165 | 0.87 | PTGS2 (0.51) | PTGS2PTGS1ALDH1A1 | |
| SCHEMBL8635921 | 0.86 | PTGS2 (0.46) | PTGS2PTGS1 | |
| Benzene SCHEMBL7058431 | 0.85 | PTGS2 (0.51) | PTGS2PTGS1 | |
| SCHEMBL8618309 | 0.85 | PTGS2 (0.51) | PTGS2PTGS1 | |
| SCHEMBL8688398 | 0.84 | PTGS1 (0.53) | PTGS2PTGS1ALDH1A1MMP2MMP1 | |
| SCHEMBL8420779 | 0.84 | ALDH1A1 (0.41) | PTGS2PTGS1ALDH1A1MMP2MMP1 | |
| SCHEMBL8639178 | 0.83 | PTGS2 (0.43) | PTGS2PTGS1ALDH1A1MMP2MMP1 | |
| SCHEMBL8688703 | 0.83 | PTGS2 (0.41) | PTGS2PTGS1ALDH1A1 | |
| SCHEMBL8641068 | 0.83 | PTGS2 (0.53) | PTGS2PTGS1ALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | claimed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5753688-A | ANTIINFLAMMATORY | TALLEY JOHN J (US) | 1998-05-19 | — | — | US | disclosed |
| US-5510496-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5504215-A | Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-04-02 | — | — | US | disclosed |